After a decade as the anchor of "NBC Nightly News," Lester Holt is starting a new chapter in his journalism career. | USA TODAY Video

Lester Holt signs off at the end of his first broadcast as anchor of #NBCNightlyNews | NBC Nightly News with Tom Llamas

"President Trump and North Korean leader Kim Jong Un waking up just a half-mile from each other on what is already a Monday morning here in Singapore." Lester Holt anchors NBC Nightly News ahead of the historic summit. MORE: https://nbcnews.to/2kZrw1v | NBC Nightly News with Tom Llamas

Here's Lester Holt with a preview of what's ahead on tonight's broadcast. Join us for NBC Nightly News at 6:30 pm ET / 5:30 pm CT (check local station listings). | NBC Nightly News with Tom Llamas

Gov. Cuomo responds to President Trump, who said he doesn't believe New York needs 30,000 ventilators. "I hope no one needs a ventilator," Cuomo told Lester Holt today. "But I don't operate on what I hope...I operate on the data..." Watch the interview tonight on Nightly News. | NBC Nightly News with Tom Llamas

TONIGHT: Lester Holt interviews Dr. Anthony Fauci as the US adds travel restrictions in response to the Omicron Covid-19 variant. We'll have the latest tonight on NBC Nightly News at 6:30 ET / 5:30 CT (check your local NBC station listings). Read more: https://nbcnews.to/3p4LxV5 | NBC Nightly News with Tom Llamas

"One pill could kill. One pill, one time, game over." Tonight on NBC Nightly News, Lester Holt talks to Cheri Oz, Special Agent in Charge of the DEA's Phoenix Field Division, about the fentanyl crisis. Watch the full report at 6:30 pm ET / 5:30 pm CT (check local listings). | NBC Nightly News with Tom Llamas