From gene cloning and initial clone selection through to final cell evaluation, the continual assessment of cell count and viability is important for determining the best growing and highest producing ...

This article is based on a poster originally authored by Julia Scherzinger, Daniel Türk, and Fernando Aprile-Garcia from CYTENA GmbH. There is constant pressure to reduce timelines in mammalian cell ...

Cell line development (CLD) follows a process that has only changed slightly since it was established in the early days of biopharmaceutical development. The steps to create a stable, manufacturing ...

Choosing the right cell line is a critical part of biopharmaceutical process development. Getting it wrong can delay scaleup and hurt a drug’s commercial potential. The key to success is full ...

Cell-line development enhances biopharmaceutical production capacity and quality, but complex biologics like bsAbs and ADCs present new challenges.

Genetic modification of mammalian cells has vast use in biotherapeutics development and basic research applications. An important step early on is the isolation of clones with the desired mutation ...

To date, more than 100 clinical trials with human pluripotent stem cell (hPSC)-derived products have been initiated worldwide ...

Gene therapies offer incredible promise for treating diseases with a genetic component. Several gene therapies are already available, and adeno-associated virus (AAV) has become a popular choice for ...